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Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy

Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF (switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene transcription. Functional genomic studies revealed a remarkable mutation prevalence of SWI/SNF-encoding genes in 20–25% of all human cancers, frequent...

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Detaylı Bibliyografya
Yayımlandı:Oncogene
Asıl Yazarlar: Wanior, Marek, Krämer, Andreas, Knapp, Stefan, Joerger, Andreas C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154588/
https://ncbi.nlm.nih.gov/pubmed/33941852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01781-x
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