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An assay for human telomeric G-quadruplex DNA binding drugs

Compounds that stabilize the G-quadruplexes formed by human telomeres can inhibit the telomerase activity and are potential cancer therapies. We have developed an assay for the screening of compounds with high affinity for human telomeric G-quadruplexes (HTG). The assay uses a thiazole orange fluore...

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Detalhes bibliográficos
Main Authors: Watkins, Derrick, Ranjan, Nihar, Kumar, Sunil, Gong, Changjun, Arya, Dev P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112084/
https://ncbi.nlm.nih.gov/pubmed/24246738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.10.030
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