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Inflammation-induced repression of Foxp3-bound chromatin in regulatory T cells

The transcription factor Foxp3 is indispensable for the ability of regulatory T (Treg) cells to suppress fatal inflammation. Here, we characterized the role of Foxp3 in chromatin remodeling and regulation of gene expression in actively suppressing Treg cells in an inflammatory setting. Although geno...

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Détails bibliographiques
Auteurs principaux: Arvey, Aaron, van der Veeken, Joris, Samstein, Robert M., Feng, Yongqiang, Stamatoyannopoulos, John A., Rudensky, Alexander Y.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112080/
https://ncbi.nlm.nih.gov/pubmed/24728351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2868
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