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Inflammation-induced repression of Foxp3-bound chromatin in regulatory T cells

The transcription factor Foxp3 is indispensable for the ability of regulatory T (Treg) cells to suppress fatal inflammation. Here, we characterized the role of Foxp3 in chromatin remodeling and regulation of gene expression in actively suppressing Treg cells in an inflammatory setting. Although geno...

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Detalles Bibliográficos
Main Authors: Arvey, Aaron, van der Veeken, Joris, Samstein, Robert M., Feng, Yongqiang, Stamatoyannopoulos, John A., Rudensky, Alexander Y.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112080/
https://ncbi.nlm.nih.gov/pubmed/24728351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2868
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