Population pharmacokinetics of trastuzumab emtansine (T-DM1), a HER2-targeted antibody–drug conjugate, in patients with HER2-positive metastatic breast cancer: clinical implications of the effect of covariates

PURPOSE: Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate comprising the humanized monoclonal antibody trastuzumab linked to DM1, a highly potent cytotoxic agent. A population pharmacokinetic (PK) analysis was performed to estimate typical values and interindividual variability of T-DM1 P...

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Bibliografiske detaljer
Main Authors: Lu, Dan, Girish, Sandhya, Gao, Yuying, Wang, Bei, Yi, Joo-Hee, Guardino, Ellie, Samant, Meghna, Cobleigh, Melody, Rimawi, Mothaffar, Conte, Pierfranco, Jin, Jin Yan
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112050/
https://ncbi.nlm.nih.gov/pubmed/24939213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2500-2
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