Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody–drug conjugate in development for the treatment of HER2-positive cancer

PURPOSE: Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate comprising trastuzumab and DM1, a microtubule polymerization inhibitor, covalently bound via a stable thioether linker. To characterize the pharmacokinetics (PK) of T-DM1 in patients with human epidermal growth factor receptor 2 (H...

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Autori principali: Girish, Sandhya, Gupta, Manish, Wang, Bei, Lu, Dan, Krop, Ian E., Vogel, Charles L., Burris III, Howard A., LoRusso, Patricia M., Yi, Joo-Hee, Saad, Ola, Tong, Barbara, Chu, Yu-Waye, Holden, Scott, Joshi, Amita
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer-Verlag 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337408/
https://ncbi.nlm.nih.gov/pubmed/22271209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1817-3
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