Degradable Lipid Nanoparticles with Predictable In Vivo siRNA Delivery Activity

One of the most significant challenges in the development of clinically-viable delivery systems for RNA interference therapeutics is to understand how molecular structures influence delivery efficacy. To this end, we synthesized 1400 degradable lipidoids and evaluated their transfection ability and...

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Detalhes bibliográficos
Main Authors: Whitehead, Kathryn A., Dorkin, J. Robert, Vegas, Arturo J., Chang, Philip H., Veiseh, Omid, Matthews, Jonathan, Fenton, Owen S., Zhang, Yunlong, Olejnik, Karsten T., Yesilyurt, Volkan, Chen, Delai, Barros, Scott, Klebanov, Boris, Novobrantseva, Tatiana, Langer, Robert, Anderson, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111939/
https://ncbi.nlm.nih.gov/pubmed/24969323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5277
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