Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles

RNA interference (RNAi)-based therapeutics have significant potential for the treatment of human disease. Safe and effective delivery of RNA to target tissues remains a major barrier to realizing its clinical potential. Several factors can affect the in vivo performance of short interfering RNA (siR...

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Bibliografiske detaljer
Main Authors: Kanasty, Rosemary L, Whitehead, Kathryn A, Vegas, Arturo J, Anderson, Daniel G
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293611/
https://ncbi.nlm.nih.gov/pubmed/22252451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.294
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