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Isg15 controls p53 stability and functions

Degradation of p53 is a cornerstone in the control of its functions as a tumor suppressor. This process is attributed to ubiquitin-dependent modification of p53. In addition to polyubiquitination, we found that p53 is targeted for degradation through ISGylation. Isg15, a ubiquitin-like protein, cova...

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Detalhes bibliográficos
Main Authors: Huang, Yi-Fu, Wee, Sheena, Gunaratne, Jayantha, Lane, David P, Bulavin, Dmitry V
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111675/
https://ncbi.nlm.nih.gov/pubmed/24844324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29209
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