Primate evolution of the recombination regulator PRDM9

The PRDM9 gene encodes a protein with a highly variable tandem-repeat zinc finger (ZF) DNA-binding domain that plays a key role in determining sequence-specific hotspots of meiotic recombination genome-wide. Here we survey the diversity of the PRDM9 ZF domain by sequencing this region in 64 primates...

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Main Authors: Schwartz, Jerrod J., Roach, David J., Thomas, James H., Shendure, Jay
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110516/
https://ncbi.nlm.nih.gov/pubmed/25001002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5370
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