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Recombination regulator PRDM9 influences the instability of its own coding sequence in humans
PRDM9 plays a key role in specifying meiotic recombination hotspot locations in humans and mice via recognition of hotspot sequence motifs by a variable tandem-repeat zinc finger domain in the protein. We now explore germ-line instability of this domain in humans. We show that repeat turnover is dri...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545772/ https://ncbi.nlm.nih.gov/pubmed/23267059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220813110 |
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