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PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans
PRDM9 has recently been identified as a likely trans-regulator of meiotic recombination hot spots in humans and mice1-3. The protein contains a zinc finger array that in humans can recognise a short sequence motif associated with hot spots4, with binding to this motif possibly triggering hot-spot ac...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3092422/ https://ncbi.nlm.nih.gov/pubmed/20818382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.658 |
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