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Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations
PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of its zinc-finger repeat array to a DNA sequence motif associated with hotspots. However, our view of PRDM9 regulation, in terms of motifs defined and hotspots studied, has a strong bias toward the PRDM9 A vari...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145720/ https://ncbi.nlm.nih.gov/pubmed/21750151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109531108 |
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