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PRDM9 is a Major Determinant of Meiotic Recombination Hotspots in humans and mice
Meiotic recombination events cluster into narrow segments of the genome, defined as hotspots. Here, we demonstrate that a major player for hotspot specification is the Prdm9 gene. First, two mouse strains that differ in hotspot usage are polymorphic for the zinc finger DNA binding array of PRDM9. Se...
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| Publicado no: | Science |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4295902/ https://ncbi.nlm.nih.gov/pubmed/20044539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1183439 |
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