PRDM9 is a Major Determinant of Meiotic Recombination Hotspots in humans and mice

Meiotic recombination events cluster into narrow segments of the genome, defined as hotspots. Here, we demonstrate that a major player for hotspot specification is the Prdm9 gene. First, two mouse strains that differ in hotspot usage are polymorphic for the zinc finger DNA binding array of PRDM9. Se...

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發表在:Science
Main Authors: Baudat, F., Buard, J., Grey, C., Fledel-Alon, A., Ober, C., Przeworski, M., Coop, G., de Massy, B.
格式: Artigo
語言:Inglês
出版: 2009
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295902/
https://ncbi.nlm.nih.gov/pubmed/20044539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1183439
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