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iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function
iRHOM2 is a highly conserved, catalytically inactive member of the Rhomboid family, which has recently been shown to regulate the maturation of the multi-substrate ectodomain sheddase enzyme ADAM17 (TACE) in macrophages. Dominant iRHOM2 mutations are the cause of the inherited cutaneous and oesophag...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4110483/ https://ncbi.nlm.nih.gov/pubmed/24643277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu120 |
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