Comparative Impacts Over 5 Years of Artemisinin-Based Combination Therapies on Plasmodium falciparum Polymorphisms That Modulate Drug Sensitivity in Ugandan Children

Background. Artemisinin-based combination therapies, including artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP), are recommended to treat uncomplicated falciparum malaria. Sensitivities to components of AL and DP are impacted by polymorphisms in pfmdr1 and pfcrt. We monitored cha...

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Detalhes bibliográficos
Main Authors: Conrad, Melissa D., LeClair, Norbert, Arinaitwe, Emmanuel, Wanzira, Humphrey, Kakuru, Abel, Bigira, Victor, Muhindo, Mary, Kamya, Moses R., Tappero, Jordan W., Greenhouse, Bryan, Dorsey, Grant, Rosenthal, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110461/
https://ncbi.nlm.nih.gov/pubmed/24610872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu141
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