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Myopathy-causing Mutations in an HSP40 Chaperone Disrupt Processing of Specific Client Conformers

The molecular chaperone network protects against the toxic misfolding and aggregation of proteins. Disruption of this network leads to a variety of protein conformational disorders. One such example recently discovered is limb-girdle muscular dystrophy type 1D (LGMD1D), which is caused by mutation o...

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Autori principali: Stein, Kevin C., Bengoechea, Rocio, Harms, Matthew B., Weihl, Conrad C., True, Heather L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110315/
https://ncbi.nlm.nih.gov/pubmed/24920671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.572461
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