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Structural basis for client recognition and activity of Hsp40 chaperones

Hsp70 and Hsp40 chaperones work synergistically in a wide range of biological processes including protein synthesis, membrane translocation, and folding. We used NMR spectroscopy to determine the solution structure and dynamic features of an Hsp40 in complex with an unfolded client protein. Atomic s...

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Bibliografski detalji
Izdano u:Science
Glavni autori: Jiang, Yajun, Rossi, Paolo, Kalodimos, Charalampos G.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023980/
https://ncbi.nlm.nih.gov/pubmed/31604242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax1280
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