HIV-1 Envelope Proteins and V1/V2 Domain Scaffolds with Mannose-5 to Improve the Magnitude and Quality of Protective Antibody Responses to HIV-1

Two lines of investigation have highlighted the importance of antibodies to the V1/V2 domain of gp120 in providing protection from HIV-1 infection. First, the recent RV144 HIV-1 vaccine trial documented a correlation between non-neutralizing antibodies to the V2 domain and protection. Second, multip...

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Hlavní autoři: Morales, Javier F., Morin, Trevor J., Yu, Bin, Tatsuno, Gwen P., O'Rourke, Sara M., Theolis, Richard, Mesa, Kathryn A., Berman, Phillip W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110267/
https://ncbi.nlm.nih.gov/pubmed/24872420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.554089
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