Glycoform and Net Charge Heterogeneity in gp120 Immunogens Used in HIV Vaccine Trials

BACKGROUND: The RV144 clinical trial showed for the first time that vaccination could provide modest but significant protection from HIV-1 infection. To understand the protective response, and to improve upon the vaccine's efficacy, it is important to define the structure of the immunogens used...

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Main Authors: Yu, Bin, Morales, Javier F., O'Rourke, Sara M., Tatsuno, Gwen P., Berman, Phillip W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425498/
https://ncbi.nlm.nih.gov/pubmed/22928048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043903
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