Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike

Broadly neutralizing antibodies (bNAbs) to HIV-1 envelope glycoprotein (Env) can prevent infection in animal models. Characterized bNAb targets, although key to vaccine and therapeutic strategies, are currently limited. We defined a new site of vulnerability by solving structures of bNAb 8ANC195 com...

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Main Authors: Scharf, Louise, Scheid, Johannes F., Lee, Jeong Hyun, West, Anthony P., Chen, Courtney, Gao, Han, Gnanapragasam, Priyanthi N.P., Mares, René, Seaman, Michael S., Ward, Andrew B., Nussenzweig, Michel C., Bjorkman, Pamela J.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109818/
https://ncbi.nlm.nih.gov/pubmed/24767986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.04.001
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