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Upregulation of hepatic VLDLR via PPARα is required for the triglyceride-lowering effect of fenofibrate

The liver and the VLDL receptor (VLDLR) play major roles in TG and VLDL metabolism. However, the exact role of liver VLDLR is not well known because of the absence of or difficulty in detecting VLDLR in the liver. In this study, we demonstrate that fenofibrate, a PPARα agonist and widely used TG-low...

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Autori principali: Gao, Yang, Shen, Wei, Lu, Boyu, Zhang, Qingjiong, Hu, Yang, Chen, Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109757/
https://ncbi.nlm.nih.gov/pubmed/24899625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M041988
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