A Structurally Unique E2-Binding Domain Activates Ubiquitination by the ERAD E2, Ubc7p, Through Multiple Mechanisms

Cue1p is an integral component of yeast endoplasmic reticulum (ER)-associated degradation (ERAD) ubiquitin ligase (E3) complexes. It tethers the ERAD ubiquitin-conjugating enzyme (E2), Ubc7p, to the ER and prevents its degradation, and also activates Ubc7p via unknown mechanisms. We have now determi...

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Détails bibliographiques
Auteurs principaux: Metzger, Meredith B., Liang, Yu-He, Das, Ranabir, Mariano, Jennifer, Li, Shengjian, Li, Jess, Kostova, Zlatka, Byrd, R. Andrew, Ji, Xinhua, Weissman, Allan M.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109681/
https://ncbi.nlm.nih.gov/pubmed/23665230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.04.004
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