Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B

RING proteins constitute the largest class of E3 ubiquitin ligases. Unlike most RINGs, AO7 (RNF25) binds the E2 ubiquitin-conjugating enzyme, UbcH5B (UBE2D2), with strikingly high affinity. We have defined, by co-crystallization, the distinctive means by which AO7 binds UbcH5B. AO7 contains a struct...

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Foilsithe in:J Biol Chem
Main Authors: Li, Shengjian, Liang, Yu-He, Mariano, Jennifer, Metzger, Meredith B., Stringer, Daniel K., Hristova, Ventzislava A., Li, Jess, Randazzo, Paul A., Tsai, Yien Che, Ji, Xinhua, Weissman, Allan M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683248/
https://ncbi.nlm.nih.gov/pubmed/26475854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685867
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