Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier.

Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous phenomenon in micrometastases; poor antibody penetration, attributable to a "binding-site barrier&...

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Main Authors: Saga, T, Neumann, R D, Heya, T, Sato, J, Kinuya, S, Le, N, Paik, C H, Weinstein, J N
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC41095/
https://ncbi.nlm.nih.gov/pubmed/7568060
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