Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier.
Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous phenomenon in micrometastases; poor antibody penetration, attributable to a "binding-site barrier" phen...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1995
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41095/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568060/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.19.8999 |
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