Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier.

Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous phenomenon in micrometastases; poor antibody penetration, attributable to a "binding-site barrier" phen...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Saga, T, Neumann, R D, Heya, T, Sato, J, Kinuya, S, Le, N, Paik, C H, Weinstein, J N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41095/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568060/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.19.8999
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