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Hormesis in cancer immunology: Does the quantity of an immune reactant matter?

We recently reported that tumor-directed antibodies could either stimulate, or inhibit, tumor progression, dependent upon the dosage used. The narrow range over which this immune response curve (IRC) occurs is surprising. Here we discuss features of the IRC, the mechanisms identified so far, and the...

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Главные авторы: Pearce, Oliver MT, Läubli, Heinz, Bui, Jack, Varki, Ajit
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108457/
https://ncbi.nlm.nih.gov/pubmed/25083340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.29312
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