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Sialic acid–binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses

The mammalian immune system evolved to tightly regulate the elimination of pathogenic microbes and neoplastic transformed cells while tolerating our own healthy cells. Here, we summarize experimental evidence for the role of Siglecs—in particular CD33-related Siglecs—as self-receptors and their sial...

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Bibliografiske detaljer
Udgivet i:Cell Mol Life Sci
Main Authors: Läubli, Heinz, Varki, Ajit
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7942692/
https://ncbi.nlm.nih.gov/pubmed/31485715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03288-x
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