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Hormesis in cancer immunology: Does the quantity of an immune reactant matter?

We recently reported that tumor-directed antibodies could either stimulate, or inhibit, tumor progression, dependent upon the dosage used. The narrow range over which this immune response curve (IRC) occurs is surprising. Here we discuss features of the IRC, the mechanisms identified so far, and the...

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Detalhes bibliográficos
Main Authors: Pearce, Oliver MT, Läubli, Heinz, Bui, Jack, Varki, Ajit
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108457/
https://ncbi.nlm.nih.gov/pubmed/25083340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.29312
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