IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION GENES CONTRIBUTE TO THE INDUCTION OF THYROID STIMULATING ANTIBODIES IN RECOMBINANT INBRED MICE

Graves’ hyperthyroidism is an autoimmune disease occurring spontaneously in humans caused by autoantibodies that stimulate the thyrotropin-receptor. In mice, inducing Graves’-like hyperthyroidism requires in vivo expression of the thyrotropin-receptor using plasmid or adenovirus vectors. However, mi...

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Autores principales: Rapoport, Basil, Williams, Robert W., Chen, Chun-Rong, McLachlan, Sandra M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108286/
https://ncbi.nlm.nih.gov/pubmed/20407472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2010.8
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