A Pause Sequence Enriched at Translation Start Sites Drives Transcription Dynamics In Vivo

Transcription by RNA polymerase (RNAP) is interrupted by pauses that play diverse regulatory roles. Although individual pauses have been studied in vitro, the determinants of pauses in vivo and their distribution throughout the bacterial genome remain unknown. Using nascent transcript sequencing we...

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Main Authors: Larson, Matthew H., Mooney, Rachel A., Peters, Jason M., Windgassen, Tricia, Nayak, Dhananjaya, Gross, Carol A., Block, Steven M., Greenleaf, William J., Landick, Robert, Weissman, Jonathan S
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108260/
https://ncbi.nlm.nih.gov/pubmed/24789973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1251871
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