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Integrin αIIb Tail Distal of GFFKR Participates in Inside-out αIIbβ3 Activation
BACKGROUND: Increases in ligand binding to integrins (“activation”) play critical roles in platelet and leukocyte function. Integrin activation requires talin and kindlin binding to integrin β cytoplasmic tails. Much research has focused on the conserved GFFKR motif in integrin αIIb tails for its im...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4107134/ https://ncbi.nlm.nih.gov/pubmed/24837519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12610 |
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