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Integrin α(IIb)β(3) Inside-out Activation: AN IN SITU CONFORMATIONAL ANALYSIS REVEALS A NEW MECHANISM
Integrins are a family of heterodimeric adhesion receptors that transmit signals bi-directionally across the plasma membranes. The transmembrane domain (TM) of integrin plays a critical role in mediating transition of the receptor from the default inactive to the active state on the cell surfaces. I...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3391112/ https://ncbi.nlm.nih.gov/pubmed/22613710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.360966 |
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