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Interplay between Disulfide Bonding and N-Glycosylation Defines SLC4 Na(+)-coupled Transporter Extracellular Topography

The extracellular loop 3 (EL-3) of SLC4 Na(+)-coupled transporters contains 4 highly conserved cysteines and multiple N-glycosylation consensus sites. In the electrogenic Na(+)-HCO(3)(−) cotransporter NBCe1-A, EL-3 is the largest extracellular loop and is predicted to consist of 82 amino acids. To d...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhu, Quansheng, Kao, Liyo, Azimov, Rustam, Abuladze, Natalia, Newman, Debra, Kurtz, Ira
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342456/
https://ncbi.nlm.nih.gov/pubmed/25568315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.619320
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