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Topology of NBCe1 Protein Transmembrane Segment 1 and Structural Effect of Proximal Renal Tubular Acidosis (pRTA) S427L Mutation
In the kidney proximal tubule, NBCe1-A plays a critical role in absorbing HCO(3)(−) from cell to blood. NBCe1-A transmembrane segment 1 (TM1) is involved in forming part of the ion permeation pathway, and a missense mutation S427L in TM1 impairs ion transport, causing proximal renal tubular acidosis...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3597827/ https://ncbi.nlm.nih.gov/pubmed/23362273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404533 |
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