Topological Location and Structural Importance of the NBCe1-A Residues Mutated in Proximal Renal Tubular Acidosis

NBCe1-A electrogenically cotransports Na(+) and HCO(3)(−) across the basolateral membrane of renal proximal tubule cells. Eight missense mutations and 3 nonsense mutations in NBCe1-A cause severe proximal renal tubular acidosis (pRTA). In this study, the topologic properties and structural importanc...

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Detalhes bibliográficos
Main Authors: Zhu, Quansheng, Kao, Liyo, Azimov, Rustam, Newman, Debra, Liu, Weixin, Pushkin, Alexander, Abuladze, Natalia, Kurtz, Ira
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859501/
https://ncbi.nlm.nih.gov/pubmed/20197274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.093286
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