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Topological Location and Structural Importance of the NBCe1-A Residues Mutated in Proximal Renal Tubular Acidosis
NBCe1-A electrogenically cotransports Na(+) and HCO(3)(−) across the basolateral membrane of renal proximal tubule cells. Eight missense mutations and 3 nonsense mutations in NBCe1-A cause severe proximal renal tubular acidosis (pRTA). In this study, the topologic properties and structural importanc...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2859501/ https://ncbi.nlm.nih.gov/pubmed/20197274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.093286 |
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