Activated Hepatic Stellate Cells Are Dependent on Self-collagen, Cleaved by Membrane Type 1 Matrix Metalloproteinase for Their Growth

Stellate cells are distributed throughout organs, where, upon chronic damage, they become activated and proliferate to secrete collagen, which results in organ fibrosis. An intriguing property of hepatic stellate cells (HSCs) is that they undergo apoptosis when collagen is resolved by stopping tissu...

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Main Authors: Birukawa, Naoko Kubo, Murase, Kazuyuki, Sato, Yasushi, Kosaka, Akemi, Yoneda, Akihiro, Nishita, Hiroki, Fujita, Ryosuke, Nishimura, Miyuki, Ninomiya, Takafumi, Kajiwara, Keiko, Miyazaki, Miyono, Nakashima, Yusuke, Ota, Sigenori, Murakami, Yuya, Tanaka, Yasunobu, Minomi, Kenjiro, Tamura, Yasuaki, Niitsu, Yoshiro
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2014
נושאים:
Cell Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106337/
https://ncbi.nlm.nih.gov/pubmed/24867951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544494
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