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Activated Hepatic Stellate Cells Are Dependent on Self-collagen, Cleaved by Membrane Type 1 Matrix Metalloproteinase for Their Growth

Stellate cells are distributed throughout organs, where, upon chronic damage, they become activated and proliferate to secrete collagen, which results in organ fibrosis. An intriguing property of hepatic stellate cells (HSCs) is that they undergo apoptosis when collagen is resolved by stopping tissu...

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Detalhes bibliográficos
Main Authors: Birukawa, Naoko Kubo, Murase, Kazuyuki, Sato, Yasushi, Kosaka, Akemi, Yoneda, Akihiro, Nishita, Hiroki, Fujita, Ryosuke, Nishimura, Miyuki, Ninomiya, Takafumi, Kajiwara, Keiko, Miyazaki, Miyono, Nakashima, Yusuke, Ota, Sigenori, Murakami, Yuya, Tanaka, Yasunobu, Minomi, Kenjiro, Tamura, Yasuaki, Niitsu, Yoshiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106337/
https://ncbi.nlm.nih.gov/pubmed/24867951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544494
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