Activated Hepatic Stellate Cells Are Dependent on Self-collagen, Cleaved by Membrane Type 1 Matrix Metalloproteinase for Their Growth

Stellate cells are distributed throughout organs, where, upon chronic damage, they become activated and proliferate to secrete collagen, which results in organ fibrosis. An intriguing property of hepatic stellate cells (HSCs) is that they undergo apoptosis when collagen is resolved by stopping tissu...

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Dades bibliogràfiques
Autors principals: Birukawa, Naoko Kubo, Murase, Kazuyuki, Sato, Yasushi, Kosaka, Akemi, Yoneda, Akihiro, Nishita, Hiroki, Fujita, Ryosuke, Nishimura, Miyuki, Ninomiya, Takafumi, Kajiwara, Keiko, Miyazaki, Miyono, Nakashima, Yusuke, Ota, Sigenori, Murakami, Yuya, Tanaka, Yasunobu, Minomi, Kenjiro, Tamura, Yasuaki, Niitsu, Yoshiro
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106337/
https://ncbi.nlm.nih.gov/pubmed/24867951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544494
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