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Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target

Work over the past 4 years indicates that multiple proteins associated with neurodegenerative diseases, especially Tau and α-synuclein, can propagate aggregates between cells in a prion-like manner. This means that once an aggregate is formed it can escape the cell of origin, contact a connected cel...

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Autori principali: Holmes, Brandon B., Diamond, Marc I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106306/
https://ncbi.nlm.nih.gov/pubmed/24860099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R114.549295
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