Phase II Randomized, Double-Blinded Comparison of A Single High Dose (5×10(8) TCID(50)) of Modified Vaccinia Ankara Compared To A Standard Dose (1×10(8) TCID(50)) in Healthy Vaccinia-Naïve Individuals

INTRODUCTION: Reintroduction of Variola major as an agent of bioterrorism remains a concern. Time to seroconversion and plaque reduction neutralizing antibody titers (PRNT) of 1 or 2 standard doses (SD) were compared to a single high dose (HD) of modified vaccinia Ankara (MVA). METHODS: Ninety subje...

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Autori principali: Frey, Sharon E., Winokur, Patricia L., Hill, Heather, Goll, Johannes B., Chaplin, Paul, Belshe, Robert B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106233/
https://ncbi.nlm.nih.gov/pubmed/24607004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2014.02.043
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