Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels

BACKGROUND: The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is a chloride channel that primarily resides in airway epithelial cells. Decreased CFTR expression and/or function lead to impaired airway surface liquid (ASL) volume homeostasis, resulting in accumulation of mucus, reduced c...

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Bibliographic Details
Main Authors: Hassan, Fatemat, Xu, Xiaohua, Nuovo, Gerard, Killilea, David W, Tyrrell, Jean, Da Tan, Chong, Tarran, Robert, Diaz, Philip, Jee, Junbae, Knoell, Daren, Boyaka, Prosper N, Cormet-Boyaka, Estelle
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106203/
https://ncbi.nlm.nih.gov/pubmed/24957904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-15-69
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