A truncated CFTR protein rescues endogenous ΔF508-CFTR and corrects chloride transport in mice

Cystic fibrosis (CF) is most frequently associated with deletion of phenylalanine at position 508 (ΔF508) in the CF transmembrane conductance regulator (CFTR) protein. The ΔF508-CFTR mutant protein exhibits a folding defect that affects its processing and impairs chloride-channel function. This stud...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Cormet-Boyaka, Estelle, Hong, Jeong S., Berdiev, Bakhram K., Fortenberry, James A., Rennolds, Jessica, Clancy, J. P., Benos, Dale J., Boyaka, Prosper N., Sorscher, Eric J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Federation of American Societies for Experimental Biology 2009
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775001/
https://ncbi.nlm.nih.gov/pubmed/19620404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-127878
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi