Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines

BACKGROUND: Exportin 1 (XPO1, also known as CRM1), is a chaperone protein responsible for the export of over 200 target proteins out of the nucleus. The expression and activity of XPO1 is upregulated in several human cancers and its expression is also linked to the development of chemotherapy resist...

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Main Authors: Breit, Megan N, Kisseberth, William C, Bear, Misty D, Landesman, Yosef, Kashyap, Trinayan, McCauley, Dilara, Kauffman, Michael G, Shacham, Sharon, London, Cheryl A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4105800/
https://ncbi.nlm.nih.gov/pubmed/25022346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1746-6148-10-160
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