Preclinical Evaluation of the Novel, Orally Bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in Spontaneous Canine Cancer: Results of a Phase I Study

BACKGROUND: The purpose of this study was to evaluate the activity of Selective Inhibitors of Nuclear Export (SINE) compounds that inhibit the function of the nuclear export protein Exportin 1 (XPO1/CRM1) against canine tumor cell lines and perform a Phase I clinical trial of KPT-335 in dogs with sp...

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Detalhes bibliográficos
Main Authors: London, Cheryl A., Bernabe, Luis Feo, Barnard, Sandra, Kisseberth, William C., Borgatti, Antonella, Henson, Mike, Wilson, Heather, Jensen, Kiersten, Ito, Daisuke, Modiano, Jaime F., Bear, Misty D., Pennell, Michael L., Saint-Martin, Jean-Richard, McCauley, Dilara, Kauffman, Michael, Shacham, Sharon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913620/
https://ncbi.nlm.nih.gov/pubmed/24503695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087585
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