CtIP maintains stability at common fragile sites and inverted repeats by an end resection-independent endonuclease activity

Chromosomal rearrangements often occur at genomic loci with DNA secondary structures, such as common fragile sites (CFSs) and palindromic repeats. We developed assays in mammalian cells that revealed CFS-derived AT-rich sequences and Alu inverted repeats (Alu-IRs) are mitotic recombination hotspots,...

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Detalhes bibliográficos
Main Authors: Wang, Hailong, Li, Yongjiang, Truong, Lan N., Shi, Linda Z., Hwang, Patty Yi-Hwa, He, Jing, Do, Johnny, Cho, Michael Jeffrey, Li, Hongzhi, Negrete, Alejandro, Shiloach, Joseph, Berns, Michael W., Shen, Binghui, Chen, Longchuan, Wu, Xiaohua
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4105207/
https://ncbi.nlm.nih.gov/pubmed/24837675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.012
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