A β3 integrin-KRAS-RalB complex drives tumor stemness and resistance to EGFR inhibition

Tumor cells, with stem-like properties, are highly aggressive and often display drug resistance. Here, we reveal that integrin αvβ3 serves as a marker of breast, lung, and pancreatic carcinomas with stem-like properties that are highly resistant to receptor tyrosine kinase inhibitors such as erlotin...

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Autori principali: Seguin, Laetitia, Kato, Shumei, Franovic, Aleksandra, Camargo, M. Fernanda, Lesperance, Jacqueline, Elliott, Kathryn C., Yebra, Mayra, Mielgo, Ainhoa, Lowy, Andrew M., Husain, Hatim, Cascone, Tina, Diao, Lixia, Wang, Jing, Wistuba, Ignacio I., Heymach, John V., Lippman, Scott M., Desgrosellier, Jay S., Anand, Sudarshan, Weis, Sara M., Cheresh, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4105198/
https://ncbi.nlm.nih.gov/pubmed/24747441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2953
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