Exploration of Alternate Catalytic Mechanisms and Optimization Strategies for Retroaldolase Design

Designed retroaldolases have utilized a nucleophilic lysine to promote carbon–carbon bond cleavage of β-hydroxy-ketones via a covalent Schiff base intermediate. Previous computational designs have incorporated a water molecule to facilitate formation and breakdown of the carbinolamine intermediate t...

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Detalhes bibliográficos
Main Authors: Bjelic, Sinisa, Kipnis, Yakov, Wang, Ling, Pianowski, Zbigniew, Vorobiev, Sergey, Su, Min, Seetharaman, Jayaraman, Xiao, Rong, Kornhaber, Gregory, Hunt, John F., Tong, Liang, Hilvert, Donald, Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104579/
https://ncbi.nlm.nih.gov/pubmed/24161950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.10.012
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