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Crystal structure of a catalytically active GG(D/E)EF diguanylate cyclase domain from Marinobacter aquaeolei with bound c-di-GMP product

Recent studies of signal transduction in bacteria have revealed a unique second messenger, bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP), which regulates transitions between motile states and sessile states, such as biofilms. C-di-GMP is synthesized from two GTP molecules by diguanylate cyclases (DGC)....

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Autors principals: Vorobiev, Sergey M., Neely, Helen, Yu, Bomina, Seetharaman, Jayaraman, Xiao, Rong, Acton, Thomas B., Montelione, Gaetano T., Hunt, John F.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683829/
https://ncbi.nlm.nih.gov/pubmed/22843345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10969-012-9136-4
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